Targeted Deletion of Kcne2 Causes Gastritis Cystica Profunda and Gastric Neoplasia
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چکیده
منابع مشابه
Targeted Deletion of Kcne2 Causes Gastritis Cystica Profunda and Gastric Neoplasia
Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising the KCNQ1 alpha subunit and the KCNE2 beta subunit provide a K(+) efflux current to facilitate gastric acid secretion by the apical H(+)K(+)ATPase. A...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0011451